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Creation of monoclonal antibodies against tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor alpha (TFG-alpha) , their definition and possible use

Bebök, Z.; Szekeres, G.; Horváth, G.; Duda, E.; Németh, P.

Orvosi Hetilap 134(24): 1303-1307

1993

ISSN/ISBN: 0030-6002
PMID: 8332347
Document Number: 405923
These antibodies were characterised immunoserologically and immunohistochemically. The antibodies proved suitable in the detection of TNF-alpha and TGF-alpha production by different cells and tissues. These anti-TNF-alpha specific monoclonal antibodies were able to inhibit the cytotoxic effect of hrTNF-alpha in vitro. These monoclonal antibodies may potentially be useful in the future for determining TNF-alpha or TGF-alpha level by different immunodiagnostical assays (ELISA, RIA, FIA) in the medical practice.

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