A new process of cancer prevention mediated through inhibition of tumor necrosis factor alpha expression
Suganuma, M.; Okabe, S.; Sueoka, E.; Iida, N.; Komori, A.; Kim, S.J.; Fujiki, H.
Cancer Research 56(16): 3711-3715
1996
ISSN/ISBN: 0008-5472 PMID: 8706012 Document Number: 461186
Mechanisms of cancer prevention were studied using structurally different cancer-preventive agents, sarcophytol A, canventol, (-)-epigallo-catechin gallate, and tamoxifen, based on our evidence that tumor necrosis factor alpha (TNF-alpha) acts as an endogenous tumor promoter relevant to human carcinogenesis. Pretreatment with the four preventive agents commonly inhibited TNF-alpha mRNA expression and TNF-alpha release in BALB/3T3 cells induced by a tumor promoter, okadaic acid, whereas the expression of early response genes (c-jun, junB, c-fos, and fosB) was enhanced. These results strongly suggest that inhibition of TNF-alpha mRNA expression and its release is a new process of cancer prevention.