Experimental atherosclerosis in goats
Kaul, P.L.; Prasad, M.C.
Research in Veterinary Science 44(3): 383-385
1988
ISSN/ISBN: 0034-5288 PMID: 3406535 Document Number: 318805
Varying degrees of aortic sudanophilia (5 to 75 per cent) comparable to human atherosclerotic lesions (fatty streaks/spots) developed in all nine experimental goats receiving 2 g of protected cholesterol daily for two, four and nine months. From the fifth month onward, the serum cholesterol level stabilised at 450 to 525 mg 100 ml-1. Aortic sudanophilia developed after two months but without any appreciable intimal thickening. Pronounced intimal thickening with foam cells was seen after four to nine months. The development of fatty streaks/spots was directly proportional to the degree of hypercholesterolaemia and duration of protected cholesterol feeding. It was concluded that goats could be useful in comparative atherosclerosis research.