Synthesis and pharmacologic activity of 3-quinolizidine-1'-yl-5-R-indoles
Boido-Canu, C.; Boido, V.; Sparatore, F.; Sparatore, A.
Il Farmaco; Edizione Scientifica 43(10): 801-817
1988
ISSN/ISBN: 0430-0920 PMID: 3240831 Document Number: 315487
By acid action on the mixture of homolupinal diethylacetal and arylhydrazines several 3-quinolizidin-1'-yl-5-R-indoles (III a - III e) were prepared. The homolupinal diethylacetal, whose hydrolysis gives rise to the unknown aldehyde, was obtained through the action of lupinylmagnesium chloride on diethylphenylorthoformate. Compounds (III) were subjected to wide pharmacological screening; all of them exhibited calcium blocking, negative cardioinotropic and diuretic activities, while single compounds showed antiinflammatory (III d), anticonvulsant and hypoglycemic (III e) activities.