Synthesis and pharmacologic study of diethyl N-palmitoyl glutamate
Vamvakides, A.; Kolocouris, N.
Annales Pharmaceutiques Francaises 47(4): 205-212
1989
ISSN/ISBN: 0003-4509 PMID: 2637642 Document Number: 335303
The diethyl N-palmitoyl glutamate (DEEPGt) was synthesized by the mixed anhydrides method and pharmacologically studied; hypothermy, sedation, myorelaxation and antagonism of the pentetrazole (PTZ) convulsions were obtained in mice. The haloperidol catalepsy's potentiation coming with oral dyskinesias were observed on rats. It seems, in the light of the pharmacological exploration, that DEEPGt penetrates easily in the brain and develops an anti-glutamatergic activity. It is probably the slow liberation of N-palmitoyl glutamic acid (PGt) from the DEEPGt which amplifies its anti-PTZ activity and could be interesting against the memory impairing action of all the glutamatergic antagonists which are actually considered as the possible next generation of antiepileptic and neuroprotecting drugs.