Emetine therapy in the presence of heart disease
Sodeman, W.A.
Journal of Laboratory and Clinical Medicine 33(11): 1457
1948
ISSN/ISBN: 0022-2143 PMID: 18933515 Document Number: 3131
Despite usual warnings that emetine should not be administered to cardiac patients, dangers from hepatic amebic disease at times outweigh those that may result to the heart from emetine and treatment should be instituted. The added risk in the use of emetine under these circumstances, when its need is great, must be accepted. Adjustment of dosage schedules to fall within 1 mg. per kilogram body weight daily -for ten days was, in the eight patients cited, effective for the amebiasis and was accompanied by no demonstrable adverse effects on. the already damaged cardiovascular system. The use of emetine in the presence of heart disease is. discouraged except when necessary for :forms of amebiasis endangering the patient's life and not effectively treated otherwise.
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