Clinical trials on cefuzonam in obstetrics and gynecological infections
Ikeno, N.; Takahashi, K.; Yamamoto, H.; Watanabe, M.; Kishi, H.; Watanabe, Y.; Mouri, H.; Endo, H.; Shima, I.; Morizuka, T.
Japanese Journal of Antibiotics 40(10): 1741-1744
1987
ISSN/ISBN: 0368-2781 PMID: 3327963 Document Number: 298709
Ten patients (3 cases of abscess of vaginal cuff, 1 case of abscess of vaginal cuff complicated with parametritis, 2 cases of pyrosalpinx, 1 case each of abscess) of abdominal wall, pelvic cellulitis, pyometra with cervical cancer and paraovarian abscess were treated with cefuzonam (CZON), which was administered by intravenous drip infusion at a dose of 1,000 mg twice a day for 3 to 10 days (6 g to 19 g total). The clinical effectiveness reached 70.0% including 1 excellent case, 6 good cases and 3 poor cases. Bacteria were detected in all the 10 cases, and with CZON treatment, bacterial eradication were obtained in 3 cases, bacteria decreased in 3 cases, no change in 2 cases and bacterial replacement occurred in 2 cases. No abnormal laboratory findings and side effects were noted. From the above results, CZON seemed to be a highly effective and useful agent for gynecological infections.