Clinical evaluation of sulbactam/cefoperazone for infections in the field of obstetrics and gynecology
Chimura, T.; Inoue, K.; Morisaki, N.
Japanese Journal of Antibiotics 37(10): 1928-1933
1984
ISSN/ISBN: 0368-2781 PMID: 6094871 Document Number: 229899
A daily dose of 2 or 4 grams of sulbactam/cefoperazone (SBT/CPZ) by drip infusion was given to 12 patients with gynecological infections and the results were as follows. The clinical effect was judged excellent in 2 cases, good in 9 cases, and poor in 1 case and the effectiveness rate was 91.7%. Except for Streptococcus faecalis, the bacteriological effect was sufficient. A good effect was also seen in Pseudomonas cepacia organism resistant to other cephem antibiotics. Diarrhea was observed in 1 patient, and increases in GOT and GPT, possibly attributable to concomitantly used anticancer agents, were detected in another patient. In conclusion, SBT/CPZ with a 91.7% efficacy rate was useful in infections caused by beta-lactamas producing organisms and, thus, a useful agent for gnecological infections. (author's modified)