Clinical studies on ceftriaxone in the field of obstetrics and gynecology
Murakami, M.; Deguchi, H.; Masuzaki, H.; Yamabe, T.
Japanese Journal of Antibiotics 38(1): 13-17
1985
ISSN/ISBN: 0368-2781 PMID: 3989973 Document Number: 262720
Clinical studies were performed on ceftriaxone (CTRX, Ro 13-9904), a new long-acting cephalosporin antibiotic. Following a single i.v. injection of 1 g, the transfer fo CTRX to the internal gential organs was good. The transfer of CTRX to exudate of the dead space of pelvis was also good. Elbow vein and uterine artery blood serum levels revealed marked increase immediately after administration, then followed by gradual reduction at very slow rate. CTRX was given to 3 patients of female genital infections [Staphylococcus epidermidis, Candida, Escherichia coli, Streptococcus faecalis and Staphylococcus epidermidis]. Efficacy was excellent in 1 case and good in 2 cases. Two cases of diarrhea and 1 case of leukopenia were observed.