Clinical studies on imipenem/cilastatin sodium in the field of obstetrics and gynecology
Chimura, T.; Morisaki, N.; Matsuo, M.
Japanese Journal of Antibiotics 39(6): 1519-1525
1986
ISSN/ISBN: 0368-2781 PMID: 3463793 Document Number: 282259
The penetration of imipenem/cilastatin sodium (MK-0787/MK-0791) into tissues of 6 patients and clinical efficacy in 21 patients with infectious diseases were studied in the field of obstetrics and gynecology. The results are summarized below. The transfer of MK-0787/MK-0791 into genital organ tissues was very good. The clinical efficacy was evaluated for 11 patients with intrauterine infections, 5 patients with intrapelvic infections and 5 patients with other infections. Clinical responses were excellent in 7 (33.3%), good in 13 (61.9%) and poor in 1 patient (4.8%), and the efficacy rate was 95.2 percent. Infective bacteria were eradicated in 4, diminished in 2, unchanged in 1 and replaced by other bacteria in 2 patients. No side effect was observed.