Clinical study of intramuscular imipenem/cilastatin sodium in the field of obstetrics and gynecology
Matsuda, S.; Oh, K.; Tateno, M.; Kojima, Y.; Hirabayashi, K.; Okada, E.; Doko, F.; Kawai, J.
Japanese Journal of Antibiotics 44(12): 1359-1367
1991
ISSN/ISBN: 0368-2781 PMID: 1798070 Document Number: 373742
The efficacy and the safety of intramuscular imipenem/cilastatin sodium (IPM/CS) were evaluated in 22 patients with obstetric and gynecologic infections. 0.5 g/0.5 g of IPM/CS was suspended in a lidocaine solution and administered in the gluteal muscle twice a day for 3-7 days. Nineteen patients with intrauterine infections were evaluable for the clinical efficacy and 22 for the safety. 1. Clinical efficacies were excellent in 6 patients, good in 11 and poor in 2, and the efficacy rate was 89.5%. Thirteen out of 14 patients who had not responded to treatments with other previously administered antibiotics showed excellent or good responses to IPM/CS. 2. Causative bacteria were eradicated in 5 patients, decreased in 2, unchanged in 3 and replaced in 3, with an eradication rate of 61.5%. 3. Among 22 patients treated with IPM/CS, an eruption and general itching were observed in 1 patient, but no abnormal laboratory test values were observed.