Reticulocyte-dependent labeling alterations of red cell membrane in pyruvate kinase deficiency anemia
Marík, T.; Brabec, V.; Kselíková, M.; Bíbr, B.; Lener, J.
Biomedica Biochimica Acta 46(2-3): S192-S196
1987
ISSN/ISBN: 0232-766X PMID: 3593297 Document Number: 298710
The radioactive labeling of spectrin using the pentavalent complex of molybdenum-99 was applied to the study of membrane protein in pyruvate kinase deficient red cells. Compared to the control, the labeling profile of the enzymopathic red cell membrane proteins remained generally unchanged but the molybdenum uptake was found to depend largely on the reticulocyte count. This finding may reflect changes during the cell maturation.