Pharmacokinetics of diacetoxyscirpenol in cattle and swine: effects of halothane
Coppock, R.W.; Swanson, S.P.; Gelberg, H.B.; Koritz, G.D.; Buck, W.B.; Hoffmann, W.E.
American Journal of Veterinary Research 48(4): 691-695
1987
ISSN/ISBN: 0002-9645 PMID: 3592368 Document Number: 296578
In swine and cattle given 0, 0.1, or 0.5 and 0, 0.5 mg of diacetoxyscirpenol (DAS)/kg of body weight, IV, respectively; DAS had a large volume of distribution and total body clearance. The shortness of the interval between halothane and DAS exposures significantly (P greater than 0.05) decreased DAS biotransformation. Urinary excretion of DAS as a parent compound was not an important route of elimination. In swine and cattle, DAS was transformed by sequential deacetylation to monoacetoxyscirpenol and scirpentriol.