Development of combined inulin/p-aminohippuric acid (PAH) slow release implantation tablets for clearance determination in awake rats
Korsatko, W.; Sadjak, A.; Gall, P.; Supanz, S.
Die Pharmazie 42(5): 324-327
1987
ISSN/ISBN: 0031-7144 PMID: 3671443 Document Number: 295919
A new method has been developed for the simultaneous measurement of Inulin and PAH clearance in small laboratory animals (rats). An implantable Inulin/p-aminohippuric-acid matrix-retard tablet based on Eudragit was tested with the purpose to estimate renal clearances. Sufficiently high serum and urine levels of both substances can thus be maintained up to 12-48 hours. The advantage of the method is that it can be used for renal clearance tests in small conscious animals, able to move freely within their cages without serious handling stress.