Comparison between the renal clearance of endogenous creatinine and inulin in the sheep
Farningham, D.A.
Research in Veterinary Science 41(3): 410-411
1986
ISSN/ISBN: 0034-5288 PMID: 3809734 Document Number: 268936
Simultaneous renal clearances of inulin and endogenous creatinine were determined during inulin infusions in sheep. The calculated regression of creatinine on inulin clearance differed significantly from the expected line. Discrepancies might be explained by absorption and secretion of creatinine under differing conditions, but it is suggested that lack of specificity of the method used for creatinine determination is an equally likely cause. As the differences between the two clearances was not great (within the range 14 to 48 ml/min it was not significant at P<0.05), creatinine clearance remains a useful indicator of glomerular filtration. For greatest accuracy, however, inulin clearance remains the method of choice.