Stimulation of renal excretion of p-aminohippuric acid by repeated administration of drugs in young and adult rats
Storch, R.; Brünlich, H.
Acta Biologica et Medica Germanica 34(9): 1529-1539
1975
ISSN/ISBN: 0001-5318 PMID: 1221741 Document Number: 88574
The velocity of renal excretion of p-aminohippuric acid (PAH) could be raised by repeated administration of phenol red, probenecid and penicillin, which are actively transported by the acid carrier into the urine like PAH. These drugs produced an effect in fairly lower doses than PAH. The renal excretion of PAH can be accelerated by repeated pretreatment with the lipid-soluble drugs sulfaclomide, sulfamethoxypyridazine and cyclopenthiazide. It could be demonstrated that the stimulation of renal excretion of PAH by repeated administration of the investigated compounds is less pronounced in young rats than in adult animals.