Studies on combined release behaviors of versatile mini-tablets in capsule systems and fittings of their mathematical model
Li, Y-huan.; Zhu, J-bi.; Chen, S-jun.; Jia, Y-jun.
Yao Xue Xue Bao 39(6): 472-476
2004
ISSN/ISBN: 0513-4870 PMID: 15491109 Document Number: 568720
Aim To prepare nifedipine (NP) rapid release mini-tablet, sustained release mini-tablets, pulsed release mini-tablets and delayed-onset sustained release mini-tablets and develop multiplied pulsed drug delivery system (DDS), site-specific DDS, zero-order DDS and quick/slow DDS by various ways. Methods Velocity-time (v-t) equation of each mini-tablet was deduced by non-linear least square model fit. The difference of combinations in v-t profiles between theoretical value and test value was compared. Results According to the v-t equations, the combined release behaviors were observed directly from v-t profiles and the test values coincided with the theoretical profiles. Conclusion The programmed DDS, which consist of a variety of mini-tablets with different dosages and combinations in capsules, could be predicted by summing up the v-t equation of each tablet.