NMR studies of sustained release methadone tablets
Johnson, D.A.; O'Donnell, J.P.; Choulis, N.H.
Die Pharmazie 33(12): 813
1978
ISSN/ISBN: 0031-7144 PMID: 746066 Document Number: 131349
NMR studies for the identification of methadone in sustained release tablets is conducted. Up-field shifts of the N-methyl and phenyl groups of the compound were observed. These changes indicate an increased lipid solubility and therefore better absorptivity of the drug in the current form.
Document emailed within 1 workday
Related Documents
Witchitz, S.; Moisson, P.; Kolsky, H. 1984: A comparative trial of ordinary metoprolol tablets and metoprolol sustained-release tablets in hypertensive patients at rest and on exercise Pharmatherapeutica 3(8): 566-572Mellstrand, T.; Svedmyr, N.; Fagerström, P.O. 1980: Absorption of theophylline from conventional and sustained-release tablets European Journal of Respiratory Diseases. Supplement 109: 54-60
Xi, N.Z.; Tu, Z.P.; Pei, Y.Y.; Liu, D.L.; Ma, L.S.; Yang, X.Y. 1981: Calcium alginate as matrix for sustained release tablets Yao Xue Xue Bao 16(4): 277-282
Buri, P.; Doelker, E. 1980: Formulation of sustained-release tablets. II. Hydrophilic matrices Pharmaceutica Acta Helvetiae 55(7-8): 189-197
Sharma, P.L.; Sharma, R.M. 1979: Comparative bioavailability of sustained-release and conventional tablets of hydroxyethyltheophylline in man International Journal of Clinical Pharmacology and Biopharmacy 17(9): 394-396
Inouye, K.; Machida, Y.; Nagai, T. 1987: Sustained release tablets based on chitosan and carboxymethylcellulose sodium Drug Design and Delivery 1(4): 297-305
Ihlen, H.; Skomedal, T.; Stafsnes, H.; Ditlefsen, E.M. 1975: Procainamide in plasma following administration of sustained-release tablets in acute myocardial infarction Current Therapeutic Research 17(3): 257-262
Jonkman, J.H.; van der Boon, W.J.; Schoenmaker, R.; Holtkamp, A.; Thürkow-Luikens, A.J. 1984: The absolute bioavailability of a new pediatric sustained release theophylline tablet, when given as whole or divided tablets International Journal of Clinical Pharmacology Therapy and Toxicology 22(9): 506-510
Ali, A.; Iqbal, M.; Akhtar, N.; Khan, H.M.S.; Ullah, A.; Uddin, M.; Khan, M.T. 2013: Assessment of xanthan gum based sustained release matrix tablets containing highly water-soluble propranolol HCl Acta Poloniae Pharmaceutica 70(2): 283-289
Zhang, X.-Y.; Chen, D.-W.; Jin, J.; Lu, W. 2009: Artificial neural network parameters optimization software and its application in the design of sustained release tablets Yao Xue Xue Bao 44(10): 1159-1164
Palm, S.; Moenig, H.; Maier, C. 1997: Effects of oral treatment with sustained release morphine tablets on hypothalamic-pituitary-adrenal axis Methods and Findings in Experimental and Clinical Pharmacology 19(4): 269-273
Kaiko, R.F.; Fitzmartin, R.D.; Thomas, G.B.; Goldenheim, P.D. 1992: The bioavailability of morphine in controlled-release 30-mg tablets per rectum compared with immediate-release 30-mg rectal suppositories and controlled-release 30-mg oral tablets PharmacoTherapy 12(2): 107-113
Weiss, G.; Klemm, F.H.; Fuchs, W.S.; Stanislaus, F.; Zema, M.; Calanchi, M. 1998: Manufacture and in vitro characterization of a new fluid theophylline sustained-release form. Sachets with microcapsules for administration in a drinkable sustained-release suspension Arzneimittel-Forschung 48(5a): 604-612
Lutz, D.; Pabst, G.; Dahmen, W.; Molz, K.H.; Jaeger, H. 1985: Bioavailability of new nifedipine preparations in man. 1. Pharmacokinetics of nifedipine in the form of sustained-release tablets Arzneimittel-Forschung 35(12): 1840-1842
Stozek, T.; Krówczyński, L.; Bohdanowicz, T. 1983: Comparative studies on drug release from tablets in vitro and its biological availability. II. Biological availability of sodium salicylate from tablets of various formulations Acta Poloniae Pharmaceutica 40(1): 77-87
Saito, K.; Ubukata, K.; Konno, M. 1977: Studies of sustained release cephalexin (S-6437) in pediatrics Japanese Journal of Antibiotics 30(9): 672-676
Fu, C.D.; Jiang, X.T.; Hu, J.H.; Wu, W. 1996: Studies on oral sustained-release microspheres of nifedipine Yao Xue Xue Bao 31(9): 706-711
LeWitt, P.A. 1992: Clinical studies with and pharmacokinetic considerations of sustained-release levodopa Neurology 42(1 Suppl 1: 29-32; Discussion: 57-60
Regmi, B.M.; Liu, J.P.; Tu, X.D. 1996: Studies on ethmozine sustained-release tablet remaining-floating in stomach Yao Xue Xue Bao 31(1): 54-58
Alighieri, T.; Avanessian, S.; Berlini, S.; Bianchi, S.G.; Deluigi, P.; Valducci, R.; Guelen, P.J. 1988: Bioavailability of ambroxol sustained release preparations. Part I: In vitro dissolution studies Arzneimittel-Forschung 38(1): 92-94