Artificial neural network parameters optimization software and its application in the design of sustained release tablets
Zhang, X.-Y.; Chen, D.-W.; Jin, J.; Lu, W.
Yao Xue Xue Bao 44(10): 1159-1164
2009
ISSN/ISBN: 0513-4870 PMID: 20055142 Document Number: 631580
Artificial neural network (ANN) is a multi-objective optimization method that needs mathematic and statistic knowledge which restricts its application in the pharmaceutical research area. An artificial neural network parameters optimization software (ANNPOS) programmed by the Visual Basic language was developed to overcome this shortcoming. In the design of a sustained release formulation, the suitable parameters of ANN were estimated by the ANNPOS. And then the Matlab 5.0 Neural Network Toolbox was used to determine the optimal formulation. It showed that the ANNPOS reduced the complexity and difficulty in the ANN's application.