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Studies on ethmozine sustained-release tablet remaining-floating in stomach

Regmi, B.M.; Liu, J.P.; Tu, X.D.

Yao Xue Xue Bao 31(1): 54-58

1996

ISSN/ISBN: 0513-4870
PMID: 8762461
Document Number: 466820
An oral sustained-release system of ethmozine (E-HBS) was developed. The in vitro release characteristics of E-HBS were shown primarily to be of the first order of kinetics (Kr = 0.2436 h-1). The gamma-scintiphotographic study showed that E-HBS remained in the human stomach for more than 6 hours after ingestion, much longer than the conventional tablet (1 apprx 1.5 h). The plasma concentration-time curve of E-HBS exhibited typical sustained-release characteristics. The percentage of drug released in vitro vs the percentage of drug release in vivo of E-HBS indicated excellent linearity.

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