Comparative double-blind study of ketoprofen slow-release tablets and indomethacin in coxarthrosis and gonarthrosis
Gougeon, J.
La Semaine des Hopitaux Organe Fonde Par l'Association d'Enseignement Medical des Hopitaux de Paris 59(46): 3246-3248
1983
ISSN/ISBN: 0037-1777 PMID: 6318352 Document Number: 200197
This comparative trial, in which each patient acts as his own control, is an ideal model for comparing the effectiveness of both products. None of the criteria studied demonstrated a statistically significant difference in effectiveness between the two agents. Under the conditions of this study, Bi-Profenid and indomethacin can therefore be considered as having comparable potency. Study of tolerance demonstrated a superiority of Bi-Profenid over indomethacin, with excellent results in 72.5% and 66.1% of cases respectively. Specifically, digestive and above all neuro-sensory tolerance was better with Bi-Profenid. Osteoarthritis is a good indication for these medications whose effectiveness is well documented.