Studies on meperidine-induced catalepsy in mice
Aley, K.O.; Kulkarni, S.K.
Methods and Findings in Experimental and Clinical Pharmacology 9(8): 493-496
1987
ISSN/ISBN: 0379-0355 PMID: 3695733 Document Number: 294391
Anticataleptic effect of different pharmacological agents was studied against meperidine-induced (50 mg/kg i.p.) catalepsy in mice. MAO (A and B) inhibitors, alpha 2-agonists in addition to dopaminergic, GABAergic and serotoninergic agents, were found to be effective in attenuating the cataleptic symptoms. However, naloxone, an opiate antagonist, failed to reverse meperidine-induced akinesia and rigidity. Clorgyline, a specific MAO-A inhibitor, was found to be more potent than the MAO-B inhibitor selegiline.