Combined treatment with NMDA antagonist, CGP 37849, and sigma receptor agonists, SA4503 or DTG, decreases the neuroleptic-induced catalepsy in rats
Skuza, G.
Polish Journal of Pharmacology 52(4): 313-316
2000
ISSN/ISBN: 1230-6002 PMID: 11345488 Document Number: 520129
The obtained results indicate that joint administration of CGP 37849, a competitive NMDA receptor antagonist, and SA4503, a sigma1 (sigma1) receptor agonist or DTG, sigma 1/2 receptor agonist, evoked anticataleptic effect at doses which were ineffective when each of the compounds was given alone.
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