The anti-arrhythmic effect of the selective sigma-receptor antagonist DuP 734 [1- (cyclopropylmethyl) -4- (2'- (4''-fluorophenyl) -2'-oxoethyl) piper idine HBr
Maslov, L.N.; Krylatov, A.V.; Lishmanov, I.B.
Eksperimental'naia i Klinicheskaia Farmakologiia 60(2): 24-26
1997
ISSN/ISBN: 0869-2092 PMID: 9206562 Document Number: 482148
It was demonstrated on models of epinephrine-, CaCl2-, and aconitine-induced arrhythmias that the sigma-receptor antagonist DuP734 possesses high antiarrhythmic activity in a dose of 1 mg/kg. The sigma-receptor agonist-(+)SKF10,047 promoted the development of ventricular fibrillation. Atropine had no effect on the antiarrhythmic properties of DuP734. "Chemical sympathectomy" of the myocardium with the ganglion-blocking agent hexamethonium also did not affect the proarrhythmic properties of (+)SKF10,047. It is supposed that selective sigma-receptor blocking agents may be highly effective antiarrhythmic drugs.