Effect of alpha-methyl-p-tyrosine on neuroleptic-induced catalepsy in rat
Gada, V.P.; Nandal, N.V.; Balsara, J.J.; Chandorkar, A.G.
Indian Journal of Physiology and Pharmacology 27(3): 241-244
1983
ISSN/ISBN: 0019-5499 PMID: 6141998 Document Number: 211585
Pretreatment with alpha-methyl-p-tyrosine, a tyrosine hydroxylase inhibitor, was found to increase the intensity of catalepsy induced by haloperidol, chlorpromazine and molindone. The drug probably decreases the synthesis of dopamine and makes less dopamine available for release and to compete with the neuroleptic for the postsynaptic striatal dopamine receptor sites with resultant potentiation of the neuroleptic-induced catalepsy.
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