Responsiveness of the rabbit eye to adrenergic and cholinergic agonists after treatment with 6-hydroxydopamine or alpha-methyl-para-tyrosine: part II--intraocular pressure changes
Colasanti, B.K.; Trotter, R.R.
Annals of Ophthalmology 10(9): 1209-1214
1978
ISSN/ISBN: 0003-4886 PMID: 32824 Document Number: 131129
The influence of adrenergic and cholinergic drugs on intraocular pressure after chemical sympathectomy produced by 6-hydroxydopamine has been examined in rabbits. For comparison, ocular tension in response to these same drugs has been measured after chronic treatment of rabbits with the norepinephrine synthesis inhibitor alpha-methyl-para-tyrosine. The results indicated that the effects of these 2 treatments were both qualitatively and quantitatively similar. In both cases, supersensitivity to the pressure-lowering effects of alpha and beta adrenergic amines developed. After administration of cholinergic drugs, however, ocular tension became elevated to values ranging from 3 to 7 mm Hg above the baseline levels.