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Protective effect of adrenergic alpha 2-receptor agonists in hypoxic hypoxia

Kulinskiĭ, V.I.; Ol'khovskiĭ, I.A.; Kovalevskiĭ, A.N.

Biulleten' Eksperimental'noi Biologii i Meditsiny 101(6): 669-671

1986

ISSN/ISBN: 0365-9615
PMID: 2873847
Document Number: 283606
The antihypoxic effect of alpha 2-adrenoceptor agonists was studied by two different approaches: reproduction of the effect by a number of alpha 2-agonists and its blockade with selective antagonists. The data obtained suggest that alpha 2-adrenoceptor agonists increase the survival and the lifespan of mice in all the models of acute hypoxic hypoxia under study. A close correlation between antihypoxic action of alpha 2-adrenoceptor agonists and their anticalorigenic effect was established (r = +0.87; P less than 0.01).

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