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The influence of alpha-adrenergic drugs on catalepsy induced by haloperidol or fluphenazine in rats

Wielosz, M.; Kleinrok, Z.; Włoch, K.; Zebrowska-Lupina, I.

Polish Journal of Pharmacology and Pharmacy 30(5): 653-658

1978

ISSN/ISBN: 0301-0244
PMID: 35783
Document Number: 138169
Clonidine (ip) and methoxamine (ivc) inhibit the catalepsy produced by haloperidol or fluphenazine. Naphazoline and xylometazoline antagonize the catalepsy produced by haloperidol, but do not affect significantly that produced by fluphenazine. Phenylephrine did not affect the catalepsy produced by either neuroleptic. The results indicate that drugs stimulating central noradrenergic receptors antagonize the action of compounds blocking the central dopaminergic receptors.

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The influence of alpha-adrenergic drugs on catalepsy induced by haloperidol or fluphenazine in rats

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