Effect of haloperidol on changes in development of spontaneous catalepsy during subchronic injections of dopamine agonists and antagonists
Kozlovskiĭ, V.L.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 3: 75-80
2012
ISSN/ISBN: 0031-2991 PMID: 23072116 Document Number: 656719
The influence of haloperidol intracutaneous injections on the development of spontaneous catalepsy phenomenon in SHR mice which received intraperitoneal injections of d,l-amphetamine (10 mg/kg) and haloperidol (5 mg/kg) alternately during 12 days, was studied ("neurochemical aggression"). It was demonstrated that alternating injections of d,l-amphetamine and haloperidol decrease the spontaneous catalepsy duration. Daily intracutaneous injections of haloperidol (0,25 mg/kg) prevented these changes but disrupted the spontaneous catalepsy phenomenon recovery by the 10-th day of measurements. A lower dosage (0,1 mg/kg) of haloperidol did not affect the results of the research. A conclusion was made that subchronic injections of haloperidol might have a protective effect in acute period of "neurochemical aggression" but slow down brain functioning recovery.