Effect of antagonists vs agonists on in vitro fertilization outcome
Check, M.L.; Check, J.H.; Choel, J.K.; Davies, E.; Kiefer, D.
Clinical and Experimental Obstetrics and Gynecology 31(4): 257-259
2004
ISSN/ISBN: 0390-6663 PMID: 15672958 Document Number: 579466
To compare outcome following in vitro fertilization-embryo transfer (IVF-ET) using controlled ovarian hyperstimulation (COH) regimens using either the gonadotropin-releasing hormone (GnRH) agonist leuprolide acetate vs the GnRH antagonist ganirelix. Women needing IVF for conception were randomly assigned to 300 IU of gonadotropins with ganirelix used in the follicular phase when a follicle with a 14 mm average diameter was attained vs a regimen using leuprolide acetate from the mid-luteal phase of the previous cycle. There were no differences found in clinical, ongoing, delivered pregnancy rates or implantation rates between groups. The use of GnRH antagonists do not seem to reduce IVF outcome compared to using GnRH agonists in COH regimens.