Application of mouse tail artery for the study of alpha adrenoceptor agonists and antagonists and calcium antagonists
Shi, C.Z.; Li, X.M.; Liu, Y.; Zhang, J.T.
Yao Xue Xue Bao 25(3): 223-226
1990
ISSN/ISBN: 0513-4870 PMID: 1978462 Document Number: 367657
Isolated mouse tail artery strip was used to the study of .alpha.1-, .alpha.2-adrenoceptor agonists and antagonists. NA (.alpha.1 and .alpha.2 agonist) was shown to have greater activity in contracting tail artery. Phenylephrine (.alpha.1 agonist) and clonidine (.alpha.2 agonist) exhibited the same contractile action but much weaker than NA. Prazosin(.alpha.1 antagonist) and yohimbine (.alpha.2 antagonist) greatly diminished the contraction induced by phenylephrine and clonidine. These results indicate that mouse tail artery is rich in postsynaptic .alpha.1- and .alpha.2-adrenoceptor. In addition, mouse tail artery preparation was shown to be a useful tool for screening calcium agonists and antagonists. This model has advantages of being simple and easy to prepare, short equilibrium time and more economic in comparison with the helical strips of isolated rat tail artery.