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Platelet adrenergic alpha receptors in hypertensive subjects undergoing treatment with calcium antagonists

Radaelli, A.; Caporotondi, A.; Muggia, C.; Pompei, R.; Marchesi, E.

Bollettino della Societa Italiana di Biologia Sperimentale 66(1): 9-13

1990

ISSN/ISBN: 0037-8771
PMID: 2157469
Document Number: 347896
The effects of two different calcium-channel blocking agents on platelet alpha-2 adrenoceptors were studied in 18 mild to moderate hypertensive patients. The subjects were randomly assigned in a double blind fashion to treatment with either nifedipine 10 mg t.i.d. or tiapamil 300 b.i.d. for six weeks. Platelet alpha-2 receptors were studied before and following 6 weeks of treatment using radioligand binding assay (3H Rauwolscine). Both agents induced a reduction in alpha-2 receptors, which reached statistical significance only for nifedipine. Such a reduction may contribute to the antihypertensive effect of calcium-channel blocking drugs.

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Rice, H.E.; Smith, C.B.; Silk, K.R.; Rosen, J. 1984: Platelet alpha 2-adrenergic receptors in schizophrenic patients before and after phenothiazine treatment Psychiatry Research 12(1): 69-77
Holland, M.G. 1974: Autonomic drugs in ophthalmology: Some problems and promises. Section IV: Sympatholytic and sympathetic blocking agents--alpha adrenergic antagonists and beta adrenergic antagonists Annals of Ophthalmology 6(11): 1139-1142
Renouard, A.; Widdowson, P.S.; Millan, M.J. 1994: Multiple alpha 2 adrenergic receptor subtypes. I. Comparison of [3H]RX821002-labeled rat R alpha-2A adrenergic receptors in cerebral cortex to human H alpha2A adrenergic receptor and other populations of alpha-2 adrenergic subtypes Journal of Pharmacology and Experimental Therapeutics 270(3): 946-957
Hanna, M.K.; Khairallah, P.A. 1986: Alterations of myocardial alpha 1-adrenergic receptors in hypertensive cardiac hypertrophy in the rat Archives Internationales de Pharmacodynamie et de Therapie 283(1): 80-93
Fabris, B.; Fischetti, F.; Bulli, G.; Giraldi, T.; Castellano, M.; Beschi, M.G.; Carretta, R. 1991: Regulation of platelet alpha2 adrenergic receptors in a population of patients with essential arterial hypertension and in normotensive subjects Giornale Italiano di Cardiologia 21(7): 717-723
O'Hara, N.; Yokota, S.; Kouchi, Y.; Ono, H. 1986: Alpha 2-adrenergic receptors on canine platelet membranes characterized by [3H]-yohimbine binding Research Communications in Chemical Pathology and Pharmacology 52(2): 179-194
Mori, H. 1992: Study of the signal transduction system of platelet alpha 2-adrenergic receptors in endogenous depression Hokkaido Journal of Medical Science 67(2): 191-199
Radaelli, A.; Caporotondi, A.; Bongarzoni, A.; Muggia, C.; Manzinali, C.; Marchesi, E. 1990: Blood platelet alpha adrenergic receptors in congestive heart failure. Effects of ACE inhibition Recenti Progressi in Medicina 81(9): 564-567
Howard, M.J.; Hughes, R.J.; Motulsky, H.J.; Mullen, M.D.; Insel, P.A. 1987: Interactions of amiloride with alpha- and beta-adrenergic receptors: amiloride reveals an allosteric site on alpha 2-adrenergic receptors Molecular Pharmacology 32(1): 53-58
Nebigil, C.; Malik, K.U. 1992: Prostaglandin synthesis elicited by adrenergic stimuli is mediated via alpha-2C and alpha-1A adrenergic receptors in cultured smooth muscle cells of rabbit aorta Journal of Pharmacology and Experimental Therapeutics 260(2): 849-858
Mooney, J.J.; Horne, W.C.; Handin, R.I.; Schildkraut, J.J.; Alexander, R.W. 1982: Sodium inhibits both adenylate cyclase and high-affinity 3H-labeled p-aminoclonidine binding to alpha 2-adrenergic receptors in purified human platelet membranes Molecular Pharmacology 21(3): 600-608
Buccafusco, J.J.; Lapp, C.A.; Westbrooks, K.L.; Ernsberger, P. 1995: Role of medullary I1-imidazoline and alpha 2-adrenergic receptors in the antihypertensive responses evoked by central administration of clonidine analogs in conscious spontaneously hypertensive rats Journal of Pharmacology and Experimental Therapeutics 273(3): 1162-1171
Brandt, D. 1983: Calcium antagonists in the treatment of chronic arterial hypertension and hypertensive crisis Wiener Medizinische Wochenschrift 133(6): 131-135
Van Zwieten, P.A.; van Meel, J.C.; Timmermans, P.B. 1982: Calcium antagonists and alpha 2-adrenoceptors: possible role of extracellular calcium ions in alpha 2-adrenoceptor-mediated vasoconstriction Journal of Cardiovascular Pharmacology 4(Suppl 3): S273-S279
Schwartz, D.D. 1997: Activation of alpha-2 adrenergic receptors inhibits norepinephrine release by a pertussis toxin-insensitive pathway independent of changes in cytosolic calcium in cultured rat sympathetic neurons Journal of Pharmacology and Experimental Therapeutics 282(1): 248-255
Gomeza, J.; Mary, S.; Brabet, I.; Parmentier, M.L.; Restituito, S.; Bockaert, J.; Pin, J.P. 1996: Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists Molecular Pharmacology 50(4): 923-930
Shi, C.Z.; Li, X.M.; Liu, Y.; Zhang, J.T. 1990: Application of mouse tail artery for the study of alpha adrenoceptor agonists and antagonists and calcium antagonists Yao Xue Xue Bao 25(3): 223-226
Oie, S.; Chiang, J. 1989: Alteration in the pharmacologic activity of alpha 1 adrenergic antagonists by alpha-1-acid glycoprotein Progress in Clinical and Biological Research 300: 235-238
Barnes, P.J.; Dollery, C.T.; MacDermot, J. 1980: Increased pulmonary alpha-adrenergic and reduced beta-adrenergic receptors in experimental asthma Nature 285(5766): 569-571
Yamada, S.; Yamamura, H.I.; Roeske, W.R. 1980: Characterization of alpha-1 adrenergic receptors in the heart using [3H]WB4101: effect of 6-hydroxydopamine treatment Journal of Pharmacology and Experimental Therapeutics 215(1): 176-185