Minute rhythms of haloperidol catalepsy in rats

Arushanian, E.B.; Popova, A.P.

Biulleten' Eksperimental'noi Biologii i Meditsiny 101(1): 89-91

1986


ISSN/ISBN: 0365-9615
PMID: 3942822
Document Number: 268625
Haloperidol-induced (0.25-1.0 mg/kg) catalepsy in rats is characterized by rhythmic time fluctuations. Marked catalepsy was accompanied by slow regular waves at 2-4 and 5-7 min period. Natural or L-dopa-induced inhibition of the process involves the phase of irregular and frequent fluctuations. The study of time fluctuations of the muscular tone are believed important for predicting the development of drug-induced Parkinson's disease.

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