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Effect of metronidazole on immune mechanism in experimental animals

Kohli, J.; Bhattacharya, S.K.; Gupta, V.S.; Sen, P.; Chakravarty, A.K.

Indian Journal of Experimental Biology 25(3): 177-180

1987

ISSN/ISBN: 0019-5189
PMID: 3666815
Document Number: 293563
Metronidazole (10-100 mg/kg) significantly inhibited serum antibody titre against TAB vaccine in the rabbits. It also caused a significant decrease in serum anti-SRBC haemagglutination titre in doses of 50-200 mg/kg. The delayed type of hypersensitivity as revealed by footpad thickness was also significantly inhibited in mice treated with metronidazole (100 and 200 mg/kg). Metronidazole appears to have an immunosuppressant action by altering the functions of T-lymphocytes.

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