Effect of influenza virus on the immune responsiveness of animals
Kavetsky, R.E.; Savtsova, Z.D.; Struk, V.I.; Yakimenko, L.V.; Umansky, Y.A.
Acta Virologica 21(2): 109-113
1977
ISSN/ISBN: 0001-723X PMID: 17278 Document Number: 115518
Infection of mice with A/Hong Kong/1/68 (H3N2) and A/PR8/34 (H0N1) influenza virus strains resulted in a significant inhibition of the formation of antibody-producing cells in response to administration of sheep erythrocytes and a reduced capacity of spleen cells to induce "graft-versus-host" reaction. The immunosuppression caused by influenza infection was observed for a long period of time post infection (3--6 months). The extent of inhibition of antibody production depended on the dose of virus, route of inoculation, the sequence of infection and immunization and the internal between them. Heat-inactivated virus exerted no immunosuppressive effect.