Isolation and structural elucidation of clausenamide from the leaves of Clausena lansium (Lour.) Skeels

Yang, M.H.; Cao, Y.H.; Li, W.X.; Yang, Y.Q.; Chen, Y.Y.; Huang, L.

Yao Xue Xue Bao 22(1): 33-40

1987


ISSN/ISBN: 0513-4870
PMID: 3604690
Document Number: 293054
Rutaceae Clausean lansium (Lour) Skeels, widely distributed in Southern China, is a kind of fruit tree. The crude extract from its leaves has been used for the treatment of acute and chronic viral hepatitis and its effect of lowering elevated SGPT level was observed. A cyclic amide, Clausenamide, with novel structure (I) possessing the above activity has been isolated in our laboratory from the leaves of C. lansium. By means of spectrometric data combined with chemical reactions, the structure has been elucidated and the proposed structure (I) was further confirmed by X-ray diffraction analysis.

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