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Isolation and structural studies of coprine, the disulfiram-like constituent of Coprinus atramentarius

Hatfield, G.M.; Schaumberg, J.P.

Lloydia 38(6): 489-496

1975

ISSN/ISBN: 0024-5461
PMID: 1241098
Document Number: 87898
Coprine, the constituent of the mushroom Coprinus atramentarius Fr. responsible for its disulfiram-like activity, was isolated. Chemical and spectral data indicate that the compound is N5-(1-hydroxycyclopropyl)glutamine. Although coprine was shown to produce hyperaldehydemia in mice following ethanol ingestion, the compound was not found to be an inhibitor of mouse liver aldehyde dehydrogenase in vitro.

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