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Stimulation of the immune response during blockade of serotonin receptors by cyproheptadine

Idova, G.V.; Cheĭdo, M.A.

Biulleten' Eksperimental'noi Biologii i Meditsiny 103(4): 440-442

1987

ISSN/ISBN: 0365-9615
PMID: 3567337
Document Number: 291624
The role of serotonin receptors in the inhibitory effect of serotoninergic system on immunogenesis was studied using cyproheptadine, a specific blocker of 5-HT2 receptors. It was shown that cyproheptadine administration to CBA mice stimulated the immune response, which was dopamine-dependent and was realized via thymus. With the pituitary stalk destruction, the stimulatory effect of cyproheptadine was not observed, which suggests the participation of 5-HT2 brain receptors in immunogenesis.

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