Correlation between the number of serotonin type 2 receptors in the frontal cortex of the mouse brain and the expressivity of serotonin-dependent head twitches
Popova, N.K.; Kulikov, A.V.; Pak, D.F.
Biulleten' Eksperimental'noi Biologii i Meditsiny 100(9): 322-324
1985
ISSN/ISBN: 0365-9615 PMID: 3876119 Document Number: 263565
The number of serotonin type 2 receptors (S2) was measured in the frontal cortex of mice belonging to 7 inbred strains using specific 3H-spiperone binding. In the same mice, measurements were also taken of the number of 5-hydroxytryptophan-induced (200 mg/kg i.p.) of head twitches (HT). A significant positive interspecific correlation was demonstrated between the number of S2 and HT. The conclusion is drawn that in the frontal cortex 3H-spiperone is bound to functionally active S2 and that the intensity of HT is largely controlled by the genetically determined number of S2 in the brain.