Functional interplay of dopamine D1 and D2 receptors in the immune response control in different psychoemotional states
Al'perina, E.L.; Gevorgian, M.M.
Eksperimental'naia i Klinicheskaia Farmakologiia 73(6): 2-4
2010
ISSN/ISBN: 0869-2092 PMID: 20726342 Document Number: 646386
It is established that preliminary blockade ofdopamine (DA) D2 receptors with haloperidol prevents immunostimulation observed upon the activation of D1 receptors with selective agonist SKF 38393 in mice of the CBA and C57BL/6J strains having no experience in social confrontations. These data are indicative of the functional interconnection between DA receptors of the D1 and D2 subtypes in the immune response control. Similar link between these DA receptor subtypes has been also found in C57BL/6J mice conditioned to display aggressive or submissive behaviors during 10-day social encounter testing. The data obtained give evidence that the interaction between D1 and D2 receptors is manifested in animals with various genotypes and psychoemotional states.