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Prevention of the formation of the infectious process with biologically active thymic factors in the Salmonella typhimurium challenge of mice coincident with macrophage activation

Grinevich, I.A.; Zaritskiĭ, A.M.; Fil'chakov, I.V.; Fil'chakov, F.V.; Nikol'skiĭ, I.S.

Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 1987(12): 71-74

1987

ISSN/ISBN: 0372-9311
PMID: 3328454
Document Number: 289075
A single injection of thymostimulin into mice in a dose of 45 micrograms/kg b.w. enhances the functional activity of macrophages, reaching it maximum on day 10, which prevents the formation of an infectious process in mice challenged with S. typhimurium (LD50). The irradiation of the animals in a sublethal dose leads to the complete abolition of the stimulating effect of thymostimulin on macrophages. The presence of an inducer mechanism of the activation of macrophages by thymostimulin, realized in the production of lymphokines, is suggested.

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