Intragastric infection of germfree and conventional mice with Salmonella typhimurium
Nardi, R.M.; Silva, M.E.; Vieira, E.C.; Bambirra, E.A.; Nicoli, J.R.
Brazilian Journal of Medical and Biological Research 22(11): 1389-1392
1989
ISSN/ISBN: 0100-879X PMID: 2700668 Document Number: 336037
The present study investigates the lethality of intragastric Salmonella typhimurium infection of germfree (GF) and conventional (CV, not germfree) mice. The introduction of only 10 viable S. typhimurium into the gastrointestinal tract of GF mice resulted in death of all animals within 8 days of inoculation. In contrast, the 50% lethal dose for CV mice was 4.7 x 10(3) viable organisms. The results demonstrate that resident microbes protect mice from the pathogenic effect of S. typhimurium infection.