Activity of amoxicillin and ampicillin against infection with Salmonella typhimurium in mice
Avril, J.L.; Moyen, E.N.; Fauchere, J.L.; Descamps, P.; Veron, M.
Pathologie-Biologie 30(6 Part 2): 484-487
1982
ISSN/ISBN: 0369-8114 PMID: 6750518 Document Number: 194080
Experimental mouse intraperitoneal or intragastric infection due to Salmonella typhimurium C5 was treated with subcutaneous amoxicillin or ampicillin. The minimum inhibitory concentrations (MIC) and the minimum bactericidal concentrations (MBC) of the two penicillins were similar. Amoxicillin was significantly more effective than ampicillin in protecting the animals from the lethal effects of the infection. The enumeration of bacteria from spleen and Peyer's patches of the small intestine showed that amoxicillin killed S. typhimurium faster than ampicillin.