Antimutagenic activity of plumbagin in Ames Salmonella typhimurium test
Durga, R.; Sridhar, P.; Polasa, H.
Indian Journal of Medical Research 96: 143-145
1992
ISSN/ISBN: 0019-5340 PMID: 1428056 Document Number: 395122
This paper reports the antimutagenic activity of plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone) against certain known chemical mutagens in a standard mutagenicity test system of Ames using S. typhimurium strains. Plumbagin by itself did not show any mutagenic effect, whereas it reduced significantly the mutagenic effect of 4-nitrophenylene diammine, phenyl hydrazine and sodium azide in test strains of S. typhimurium, suggesting that plumbagin possessed antimutagenic activity.
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