Absorption of carbonyl iron
Huebers, H.A.; Brittenham, G.M.; Csiba, E.; Finch, C.A.
Journal of Laboratory and Clinical Medicine 108(5): 473-478
1986
ISSN/ISBN: 0022-2143 PMID: 3772228 Document Number: 286048
The mechanism of carbonyl iron absorption was studied in rats. Solubilization by gastric acid was a prerequisite for subsequent absorption. The slow rate of solubilization resulted in a more prolonged absorption, responsible for the low toxicity of carbonyl Fe. Large doses of carbonyl Fe were held for several days by the gastric mucosa of iron-deficient rats. Once it had been solubilized, the subsequent pathway of absorption by the intestinal mucosa and the amount absorbed was similar to that of ferrous ammonium sulphate.