In vitro and in vivo photochemical reactivity of quinine- and quinidine-N-oxide
Pöhlmann, H.; Theil, F.P.; Pfeifer, S.
Die Pharmazie 41(12): 859-862
1986
ISSN/ISBN: 0031-7144 PMID: 3575390 Document Number: 282779
By irradiation with UV-light quinine- and quinidine-1,1'-dioxide in polar solvents are rearranged to 2'-oxo derivatives and in nonpolar solvents to formylindol derivatives. Rats being exposed to UV-light after oral administration of quinine- or quinidine-1,1'-dioxide showed in blood plasma the 2'-oxo derivates too. In accordance with the results of the different fotochemical reactivity of quinoline-1-oxide-, chlordiazepoxide, methaqualone-1-oxide and some pyrido-pyrimidine-8-oxides a first drafting is developed due to the supposed toxic effects of the exited imino-N-oxides.