Comparison of the antiarrhythmic activity of quinidine and quinine
Klevans, L.R.; Kelly, R.J.; Kovacs, J.L.
Archives Internationales de Pharmacodynamie et de Therapie 227(1): 57-68
1977
ISSN/ISBN: 0003-9780 PMID: 901074 Document Number: 115985
A comparison was made between the effects of quinidine and quinine on experimental arrhythmias and on cardiac electrophysiologic parameters. Both drugs raised ventricular fibrillation thresholds, reversed aconitine-induced atrial fibrillation, decreased ouabain-induced abnormal ventricular beats, and increased atrial refractory periods and His-Purkinje conduction time. In contrast, only quinidine antagonized acetylcholine-induced atrial fibrillation. In addition, quinidine increased ventricular fibrillation thresholds and atrial refractory periods for a longer time period than quinine. These observations are discussed in terms of choosing an appropriate model for testing new compounds with suspected quinidine-like activity.