Comparative study of the effects on the antiarrhythmic drugs procainamide, quinidine, diphenylhidantoin and spirohidantoin compounds derived from the nor-tropane system on the potentials of membrane and transport of sodium through the frog skin
Martínez-Larrañaga, M.R.; Anadón, A.; Sanz, F.
Archivos de Farmacologia y Toxicologia 3(3): 247-258
1977
ISSN/ISBN: 0304-8616 PMID: 613982 Document Number: 120633
A comparative study was made of the influence on Na transport, membrane potentials and behavior in relation to the effects produced by isoproterenol of a group of antiarrhythmic drugs (procainamide, quinidine and diphenylhydantoin) compared with a new series of spirohydantoin compounds derived from the nor-tropane system (methyl, ethyl, isopropyl, butyl and bencyl) with possible antiarrhythmic activity. Quinidine and procainamide intensely inhibit active Na transport, the electric potential and the effects of isoproterenol. Diphenylhydantoin only inhibits the active Na transport and the electric potential in a primary phase, but the action of isoproterenol was not inhibited. With respect to the new spirohydantoin compounds a decrease of active Na transport in relation with the substituted radicals was observed, and in general significant variations in the electric potential and the effect of isoproterenol were not noted.