Antioxidant and antiarrhythmic activity of carvedilol in patients with ischemic heart disease. Comparison with anaprilin
Vasil'ev, A.P.; Strel'tsova, N.N.; Gorbunova, T.Iu.; Mal'tseva, I.A.; Zykova, E.L.
Terapevticheskii Arkhiv 73(10): 65-67
2001
ISSN/ISBN: 0040-3660 PMID: 11763521 Document Number: 538858
To examine antioxidant and antiarrhythmic activity of carvedilol vs that of standard beta-blocker anaprilin in coronary patients with low left ventricular ejection fraction (LVEF). The cross-over trial enrolled 50 coronary male patients with LVEF under 45%. Before and after treatment with carvedilol and anaprilin, measurements were made of blood dienic conjugates and malonic dialdehyde, 24-h ECG monitoring was performed. The antioxidant activity of antiarrhythmic effect of carvedilol was significantly higher than that of anaprilin. A correlation was discovered between the number of extrasystoles and blood levels of dienic conjugates. Marked antioxidant activity of carvedilol as well as reduced myocardial energy consumption resultant from hemodynamic cardiac unloading due to block of alpha-adrenoreceptors contribute to carvedilol additional antiarrhythmic effect.