Study on tissue transfer of ceftizoxime suppository in the field of obstetrics and gynecology
Yamamoto, T.; Yasuda, J.; Tomioka, M.; Kanao, M.; Okada, H.
Japanese Journal of Antibiotics 39(6): 1504-1508
1986
ISSN/ISBN: 0368-2781 PMID: 3463790 Document Number: 279353
A pharmacokinetic study on ceftizoxime suppository (CZX-S), a new rectal suppository of ceftizoxime (CZX), was carried out in the field of obstetrics and gynecology. Concentrations of CZX after single rectal administrations of a 500 mg dose in peripheral venous serum, uterine arterial serum and internal genital organs of 15 patients who received simple panhysterectomy were examined. Peak levels of CZX in peripheral venous serum were 7.26 to 8.88 micrograms/ml at 30 minutes after the administration. Concentrations of CZX in internal genital organs reached 2.12 to 8.96 micrograms/g at 30 minutes after the administration and then decreased slowly, but still remained at 0.37-3.12 micrograms/g after 4 hours.